View our Informational Materials. Thanks in part to the philanthropic support of the CEHC and other major donors, Mount Sinai leads the field both in discovering environmental causes of disease and reinventing the science on how we approach the complex impact of the environment on human health throughout the full life course. Our internationally renowned and talented team of scientists, combined with cutting-edge technology in the Senator Frank R.
Lautenberg Environment Health Sciences Laboratory, are making breakthroughs possible. For more information, please contact Erica Edwards in the Office of Development at Upcoming and recent events:. Clinical Climate Change January 12, Learn more. Children's Environmental Health Center.
follow site Recent data suggests that bacteria and viruses commonly found in the nose in early life may increase the risk of subsequent disease. This project will take advantage of a unique, community-based birth cohort ELLF , in whom the presence of respiratory viruses and bacteria in the upper airway and respiratory symptoms during the first 2 years of life have been determined from weekly nasal swabs and a daily symptom diary.
This project will determine how nasal cells obtained from either adults asthmatic or healthy and the children birth cohort respond in laboratory-based culture when infected with bacteria, in addition to assessing the cell response when co-infected with respiratory viruses.
In recent years researchers have begun focusing more on how the chemicals that we might be exposed to in early life influence our heath. The chemicals that we are specifically investigating are pesticides, specifically pyrethroid and organophosphate insecticides, and flame retardants. These chemicals are found in all homes in low levels. We need to know more about how much of these chemicals babies are exposed to before we can study the health effects properly. The aim of this study is to help provide an easy way to figure out what chemicals and how much of those chemicals Australian babies are exposed to in the home.
In this current study we want to figure out how well an online tool predicts exposure to common pesticides and flame retardants. The data we are collecting will also provide us with information that will help us determine how much of these chemicals Australian children are exposed to and how they are exposed to these chemicals. The preschool years represent a crucial period in lung development. Longitudinal studies have shown that deficits in lung function start in early life with long term consequences into adulthood.
This highlights the importance of being able to reliably and accurately measure the lung function of preschool aged children to aid in the diagnosis, treatment and management of children with suspected or known respiratory disease. Our team, together with the University of Szeged, Hungary have developed a modified version of the Forced Oscillation Technique FOT to non-invasively measure the lung function of preschool aged children.
This project aims to develop normative reference data for preschool aged children measured using the modified FOT set-up and to develop a more sensitive measure of lung function to detect changes in lung function during the preschool years. Macrophages are key cells in innate immune responses and play a critical role in orchestrating both initiation and resolution of pulmonary inflammation. In response to immune insults or injury, monocytes originated from bone-marrow migrate to the tissues, differentiate into macrophages M0 and polarize into pro-inflammatory classically activated or M1 or inflammation-resolving alternatively activated or M2 phenotypes.
These two compartments are well characterized in mouse model. In human, the border line between M1 and M2 polarization was vague until recently. Therefore macrophage responses in cystic fibrosis CF were mostly studied in mouse model. Using this model we recently reported that activation of inflammation-resolving M2 macrophages were impaired in CF. In addition, we observed early expression of pro-inflammatory M1 macrophage markers in monocyte-derived M0 macrophages in patients with CF.
We are aiming to study the link between CFTR function and macrophage polarization and functions. Injury to the airway epithelium occurs frequently as it comes in direct contact with external stimuli that cause damage and force repair. The first and most important event occurring after wounding is cell migration, and in asthma it is known to be structurally and functionally abnormal. This study will determine the key mechanisms involved in airway epithelium wound healing and establish the baseline characteristics.
Areas of collaboration include assessing the environmental contribution to the burden of disease in children, increasing the "child" focus of existing and new population health research, and developing joint education programs in children's environmental health. Strong collaborative links have been established, in particular with Professor Jochen Mueller and Professor Kevin Thomas. A seven minute video, presented by Dr Bruce Lanphear, helps people understand the population impact of exposures to environmental toxins.
The presentation is very graphical and easy to follow and ends with a list of suggestions to help avoid exposure to toxins. Watch the Video. Evidence is accumulating that climate change is resulting in a change in the distribution of infections, especially food, water, and vector-borne diseases. Such changes will result in Australia facing an increase in diseases our work force is not trained to handle.
In addition, we have seen the impact on human health of zoonoses. CHEP is collaborating on several projects investigating the impact of environmental exposures on neurodevelopment and mental health in children. Current studies are listed on the Participate in our research section of our website. This is a phase 3 multi-centre randomized placebo-controlled study of azithromycin in the primary prevention of radiologically-defined bronchiectasis in infants with cystic fibrosis.
The purpose of this study is to see if we can prevent or delay the onset of lung disease in children with Cystic Fibrosis by giving them Azithromycin from when they are very young. Total of participants have to be recruited for the study. The recruitment is still in progress for the study. The children diagnosed with cystic fibrosis by New Born Screening can be enrolled in the study by six months of age. They will receive azithromycin or placebo thrice a week till the age of 3 years. There are 14 visits to the hospital with bronchoscopy at the first visit and then at the age of 1 ad 3 years and the CT scans are done at the age of 1 and 3 years.
This is a phase 2, single-centre, double blind, randomised, placebo-controlled, study testing the primary prevention of persistent asthma in high risk children by protection against acute respiratory infections during early childhood using OM Persistent asthma is a major problem yet none of the current therapies do more than control the condition. The long-term solution is to prevent asthma from progressing to the persistent form.
The purpose of this study is to see if we can prevent asthma by stopping some of the events that happen early in life which may cause asthma. These are events like respiratory tract infections colds and flu , wheezing and sensitisation to allergens. OM is an immune-stimulant which primes the immune system so that the body can respond quickly to infections and reduce damage to the lungs to prevent asthma from developing.
OM is a capsule and powder from capsule is dissolved in water and given to the child. The child receives OM or placebo as five blocks of 10 days treatment plus 20 days no treatment for two winters and then they are followed up in the third year without any treatment. The recruitment for this study has been completed.
Environmental pediatrics, the branch of pediatric medicine that studies the influence of the environment on children's health, has in the past decade grown. Children's health and the environment: public health issues and challenges for risk assessment. To protect infants and children against toxicants, the National Research Council in called for .. Group Health Medical Associates.
There is a general lack of awareness of the particular vulnerability of children to adverse environmental exposures. CHEP has a focus on education and training, adding a children's environmental health component to Masters Level education and short summer courses in the School of Public Health, in conjunction with Dr Luke Knibbs. Excellent command of written and spoken English, experience with MS Office Applications Word, Excel, PowerPoint , excellent communications skills, attention to detail, and ability to work independently are required.
This is an unpaid position with flexible hours. A time commitment of at least one regular day per week is required.